pH-responsive polymer micelles for methotrexate delivery at tumor microenvironments

Polymer Micelles for Drug Delivery

Polymeric micelles obtained from the self-assembly of amphiphilic block copolymers are probably one of the most common drug delivery carriers among polymeric nanoparticles.1–4 The rise of highly controlled polymerization techniques, especially processes such as ATRP5 and RAFT,6 has led to an extraordinary surge of new types of block copolymers fit for biomedical applications. Facile control ove...

Stable and pH-responsive polyamidoamine based unimolecular micelles capped with a zwitterionic polymer shell for anticancer drug delivery

School of Chemical Engineering and Techno China. E-mail: [email protected]; Tel Department of Advanced Interdisciplinary S and Tissue Engineering Research Center, Aca 100850, China. E-mail: li41308@aliyun. 68166874 School of Science, Tianjin University of Com Collaborative Innovation Center of Chem Tianjin 300072, China † Electronic supplementary informatio characteristic data, additional ...

19 Polymer Micelles for Drug Delivery

Polymer micelles have been used widely in the delivery of various therapeutic drugs, which are also known as active pharmaceutical ingredients (APIs). Recent advances in drug discovery technology, including an accumulated database on therapeutic targets, combinational chemistry, and high-throughput screening (HTS), have further increased the number of candidate compounds and constructed a huge ...

FeMn2O4 nanoparticles coated dual responsive temperature and pH-responsive polymer as a magnetic nano-carrier for controlled delivery of letrozole anti-cancer

Objective(s): For cancer cells, an efficient and selective drug delivery vehicle can remarkably improve therapeutic approaches. This paper focuses on the synthesis and characterization of magnetic MnFe2O4 NPs and their incorporation in a dual temperature and pH-responsive polymer, which can serve as an efficient drug carrier. Materials and Methods: MnFe2O4 NPs were synthesized by chemical co-pr...

ph-responsive and macrophage evading low molecular weight chitosan coated nanoparticles for tumor-specific drug delivery